When discussing male reproductive aging, people typically focus on three metrics: testosterone levels, sperm concentration, and DNA fragmentation rate. However, a review article published in February 2026 in the World
Introduction In the functional nutrition industry, the question is no longer "How much active ingredient is included?" but rather "How much can the body actually utilize?" For a highly fragile
Friends working in the NAD⁺ and brain health industries have likely asked themselves the same question: NR (Nicotinamide Riboside) is widely recognized as one of the most effective NAD⁺ precursors. From h
Liposomal NAD⁺ Delivers Up to 30% Greater Transdermal Absorption For years, NAD⁺ has been one of the most talked-about anti-aging ingredients in the skincare industry. Countless brands have invested heavily in developin
V posledních letech se NAD+ bezpochyby stal jednou z nejžhavějších molekul v oblasti anti-aging a zdravé dlouhověkosti. Od vědeckých laboratoří po spotřebitelské trhy o něm nikdy neustaly diskuse.
Aging is being redefined. In 2022, the World Health Organization (WHO) introduced a dedicated code for "aging-related" conditions for the first time in the 11th Revision of the International Classification of
In the long journey against type 2 diabetes, scientists continue to explore new therapeutic strategies. Recently, a study published in the International Journal of Molecular Sciences revealed potential new mechanism
In annual pet health checkups, NT-proBNP (N-terminal pro-B-type natriuretic peptide) is a sensitive marker of myocardial stress. When its levels exceed the normal range, it usually indicates that the heart is under
When it comes to anti-aging, boosting energy, and maintaining vascular health, many people have heard of a specific term—NMN (Nicotinamide Mononucleotide). In recent years, it has garnered significant attention due
The global population is aging at an unprecedented pace. The World Health Organization (WHO) predicts that by 2050, the global population aged 60 and older will exceed 2.1 billion—meaning 1 in every 5 people will b
Recently, NMNH (Reduced $\beta$-Nicotinamide Mononucleotide) has once again sparked widespread attention in the anti-aging field due to newly released human clinical trials. Although both are precursor molecules of
V průběžném oboru výzkumu proti stárnutí se "rodina koenzymů" stala v oboru žhavým tématem. NMN, předchůdce NAD+, kdysi dobyl svět díky podpoře od známých firem
Long COVID lingers like a persistent shadow, leaving hundreds of millions worldwide struggling with brain fog, fatigue, and insomnia. In November 2025, a team from Harvard Medical School published a 24-week double-blind
V rychlém moderním životě se únava a nespavost zdají být pro mnoho lidí "častými hosty". Čelící těmto problémům vědci zjistili, že jsou spojeny s vyčerpáním "ene"
Podstatou stárnutí je buněčná "energetická krize". Jak se vědci hlouběji ponořují do výzkumu NAD+, tento koenzym se postupně stává hlavním cílem v oblasti anti-aging léčby. Studie zjistily, že dir
Ztráta energie, dušnost při stoupání po schodech, výkyvy cukru v krvi po jídle a stále těžší hubnutí tuku... Tyto tělesné pocity "stárnutí" jsou ve skutečnosti hnací silou
In April 2026, China officially released its first national consensus document: the Chinese Expert Consensus on the Role and Clinical Application of NAD⁺ in Aging-Related Diseases (2026 Edition). Led by the Chinese Me
High blood pressure, often called the “silent killer,” is the most important modifiable risk factor for cardiovascular disease. Yet many people face the same frustration: even when taking antihypertensive med
S přibývajícím stárnutím světové populace degenerativní změny v pohybovém aparátu (jako osteoartróza, osteoporóza a sarkopenie) vážně ovlivňují kvalitu života starších osob. Nejisté nohy při chůzi, di
When discussing liver health, one fundamental question arises: how can we effectively support this “biochemical factory of the human body” in its complex repair Proceses when faced with metabolic stress, fat
In the field of anti-aging, NMN (nicotinamide mononucleotide) has long been a highly regarded “star molecule.” As a direct precursor of NAD⁺, it shows great potential in energy metabolism, DNA repair, and ant
In recent years, NAD+ (nicotinamide adenine dinucleotide) has become a highly sought-after “star molecule” in the health and anti-aging field due to its tremendous potential. The most common supplements on th
For a long time, NAD (nicotinamide adenine dinucleotide) has been almost a “standard configuration” in IVD testing. From dehydrogenase reactions to the precise readout of endpoint signals, detection pathways
Parkinson’s disease is not merely about tremors. More concerning is that most patients gradually develop cognitive impairment, which may eventually progress to dementia. Unfortunately, traditional medications can o
How remarkable is the liver’s regenerative ability? Even when two-thirds of a healthy liver is surgically removed, it can restore its original size within just a few weeks. However, under conditions such as disease
V posledních letech se NAD+ často objevuje v centru populárních témat, jako je zdraví, anti-aging a kognitivní zlepšení. Zdá se, že přeskočila z laboratoře do každodenního života a stala se novou oblíbenou
In the vast world of raw materials, some names seem to rise to prominence overnight. Yet in reality, their success is never accidental. NRHM (Nicotinamide Riboside Hydrogen Malate) is one such name—frequently appe
Může se jediná molekula v lidském těle stát klíčovým faktorem zdraví srdce? Nikotinamidadenindinukleotid (NAD+) se rychle stává hlavním předmětem vědeckého výzkumu. Jako klíčový účastník energetické metaboly
Ve výzkumu mechanismů proti stárnutí si nikotinamidribosid (NR), předchůdce NAD⁺, postupně získává stále větší pozornost vědeckých institucí. V září 2023 byl vyhlášen národní patent na vynález týkající se
Když mluvíme o zdraví, střeva jsou často středem diskuse. Není zodpovědný pouze za trávení a vstřebávání živin, ale také představuje největší imunitní orgán v lidském těle. V poslední době ano
In the fields of anti-aging, cellular energy, and biotechnology, the term “NAD⁺” has almost been elevated to a mythical status. Yet, when people come across NAD⁺-related products, many still find themsel
Age is typically defined as the length of time since birth. However, a person’s true physical condition and degree of aging are better reflected by their biological age rather than the number of years they have liv
Jak povědomí o zdravém stravování stále roste, přírodní sladidla bez kalorií se stala hlavním tématem pozornosti spotřebitelů. V červnu 2025 byla studie publikována v mezinárodním časopise Food Chemistry: X systematic
While we are deeply engaged in exploring anti-aging solutions for humans, our furry companions at home are quietly facing health challenges brought on by aging—reduced energy levels, dull coats, and a slower metabo
Have you ever experienced moments like these: walking into a room and forgetting why you went there, struggling to recall a familiar name, or suffering from persistent insomnia after staying up late—followed by day
In today’s global wave of health awareness, “sugar reduction” has become a widely accepted trend. Steviol glycosides, as natural zero-calorie sweeteners, have already entered households worldwide. Howev
Recently, a study published on bioRxiv revealed the metabolic secrets behind the remarkable longevity of centenarians. Led by Boston University, the research conducted metabolomic analyses on 213 participants—
V moderním úsilí o zdraví a dlouhověkost se vědecký důraz přesunul z makroživin na buněčný energetický metabolismus. Mezi mnoha nově vznikajícími molekulami se nikotinamid ribosid (NR) stal stoupající hvězdou v oblasti life science
Jak světová populace stále stárne, řešení věkem podmíněného kognitivního úpadku a fyzického zhoršení se stalo významnou vědeckou výzvou. V dubnu 2025 byla v časopise Frontiers v Phar publikována průlomová studie
Introduction: As time quietly passes, have you noticed your once lively dog becoming slower to respond or experiencing disrupted sleep? Don’t worry — science is bringing new hope! The latest clinical trial h
Global population aging is becoming increasingly pronounced. It is estimated that by 2050, the number of people aged 65 and above will reach 1.6 billion—double the 780 million recorded in 2020. As aging progresses,
Je zde zcela nová autoritativní studie! Experiment z roku 2025 týmu Northwest A&F University, publikovaný v Journal of Microbiology (Core Journal, DOI: 10.13343/j.cnki.wsxb.20250174), byl odhalen s rigorózním dat
September 29, 2025 — After nearly three years of pressure from the Natural Products Association (NPA), the U.S. Food and Drug Administration (FDA) has reversed course and confirmed that Beta (β) Nicotinamide M
In recent years, “N-series” anti-aging dietary supplements represented by NMN and NR have continued to gain popularity in markets across Europe, the U.S., Japan, and China. The core mechanism of these product
In the world of nutrition, some substances have existed for over a hundred years but have only recently been recognized for their great value. Ergothioneine (EGT) is such a modest yet precious dietary component. △ Ch
Podle nejnovějších výzkumů publikovaných v autoritativních časopisech jako *Nature Metabolism*, data z lidské metabolomiky ukazují nelineární dramatické změny mezi 30. a 50. rokem života. Patří sem metabolismus lipidů IMB
Do you often feel exhausted? Struggled with blood sugar issues for years? Or perhaps you’re seeking anti-aging solutions and vibrant health? Today, let’s explore a powerful “energy key” hidden dee
NAD+: The Indispensable 'Cell Fuel' and 'Repairman' NAD+ is a key coenzyme involved in cellular energy metabolism (e.g., converting food into ATP), DNA repair (e.g., activating PARP enzymes), and regulat
In an age where the pursuit of 'frozen age' and 'reverse growth' is on the rise, anti-aging is no longer a distant dream. The core molecule—NAD+ (Nicotinamide Adenine Dinucleotide)—plays a cri
S rostoucím zájmem veřejnosti o zdravé stárnutí a dlouhověkost nabírá výzkum metabolismu NAD⁺ (Nikotinamid adenin dinukleotid) výrazný impuls. NMNH (redukovaný mononukleotid nikotinamidu), redu
Ženšen, známá bylina v tradiční medicíně, se používá po tisíciletí pro své nesčetné zdravotní přínosy. Středobodem jeho léčebné účinnosti jsou ginsenosidy, silné saponiny, které vzbudily zájem moderátora
Ženšen, uctívaný po staletí v tradiční čínské medicíně, je kořen známý svými pozoruhodnými terapeutickými vlastnostmi. Klíčovou součástí jeho účinnosti jsou ginsenosidy, rozmanitá skupina saponinů považovaných za aktivní s
Nicotinamide Adenine Dinucleotide Phosphate (NADP), a crucial coenzyme in cellular metabolism, serves as a cornerstone in numerous biochemical reactions. As a derivative of NAD, it adds a phosphate group which enhan
Svět biochemie je plný molekul, které, ačkoliv nejsou vždy v centru pozornosti, hrají klíčovou roli při udržování a regulaci buněčných procesů. Mezi nimi vynikají oxidované koenzymy právě díky tomu
V složitém světě biochemie hrají koenzymy klíčovou roli při usnadňování mnoha metabolických reakcí nezbytných pro život. Jedním z těchto klíčových koenzymů je nikotinamid adenin dinukleotid fosfát (NADP). Přesně to
Ve světě přírodních sladidel si stévie vydobyla významné místo díky své výjimečné sladkosti a zdravotním přínosům. Tento nulokalorický sladidlo h, pocházející z listů rostliny Stevia rebaudiana,
In the world of dietary substances, every detail matters—from the source of the ingredients to the color of the final product. For those curious about the health benefits of Nicotinamide Mononucleotide Hydrogen (NM
V proměnlivém světě zdravotních a wellness látek je hledání účinnějších řešení boje proti stárnutí a podpory buněčného zdraví neustálé. Mezi předními těmito pokroky je použití NAD+ enh
In the expansive world of biochemical research and health preservation, certain compounds emerge as particularly significant due to their potential applications and benefits. One such compound is NMNH, which sta
Nicotinamide adenine dinucleotide hydrogen (NADH) is a lesser-known yet crucial molecule in the biological sciences and various health-related fields. In this blog, we explore the wide-ranging applications of NA
Ve snaze udržet mladistvou energii a zdraví s přistárnutím vědecký výzkum neustále přináší nové látky, které mohou pomoci v tomto úsilí. Jedním z nejslibnějších je Beta-Nicotinamide Mononu
In the quest for optimal health and vitality, understanding the role of coenzymes in cellular function is paramount. Nicotinamide Adenine Dinucleotide Hydrogen (NADH) is one such coenzyme that plays a critical r
Nikotinamid adeninindinukleotid (NAD+) je základním pilířem buněčného zdraví a hraje klíčovou roli v produkci energie a metabolických procesech, které udržují život. S přibývajícím věkem hladiny NAD+ přirozeně klesají, leadin
Energy metabolism is a crucial biological Proces that involves converting food into the energy needed to power all cellular activities. It is fundamental to maintaining health, vitality, and overall well-being. One
V oblasti zdraví a wellness je udržení optimální buněčné funkce klíčem k celkové vitalitě a dlouhověkosti. Jednou z molekul, která je ústřední pro řadu biologických procesů, je nikotinamid-adenin dinukleotid, com
V honbě za vitalitou a dlouhověkostí upoutaly vědecké průlomy kolem mononukleotidu nikotinamidu (NMN) pozornost nadšenců do zdraví po celém světě. BONTAC, lídr v oblasti biochemických inovací
Při hledání zdraví a dlouhověkosti nás vědecké objevy často vedou k přírodním sloučeninám, které mohou výrazně zlepšit naši pohodu. Jedna z těchto látek, která upoutala pozornost zdravotních a wellne
V rychle se vyvíjejícím sektoru biotechnologií přetvářejí produkty získané z biologických procesů a organismů průmysl od zdravotnictví po zemědělství. Trh s biotechnologickými produkty je v Wisconsinu velmi konkurenční
V dynamickém světě zdraví a biotechnologií vyniká buněčné omlazení jako revoluční koncept, který slibuje novou éru lepšího zdraví, prodlouženého mládí a lepší kvality života. Jako vůdce v glo
In the rapidly evolving landscape of health and wellness, metabolism-boosting products have emerged as key components in enhancing human health, optimizing metabolic Proceses, and supporting various bodily functi
Introduction In the realm of animal husbandry, feed additives are necessary as they can not only improve the nutritional value of feed and optimize the internal environment of the rumen, but also enhance
Introduction Nicotinamide adenine dinucleotide (NAD) deficiency has been linked to a range of renal disorders, encompassing conditions such as acute kidney injury, diabetic nephropathy, adenine-triggered kidney diseas
Introduction In response to the escalating global obesity rates, the demand for sugar reduction has reached a critical juncture. As a strategic pivot, the food industry has increasingly incorporated sugar substitutes,
Introduction Parkinson's disease (PD), known as the silent killer, has emerged as the second most common chronic neurodegenerative disease in the world after Alzheimer's disease, affecting
Introduction Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme in cells, a central cofactor of redox reaction and a central regulator of various metabolisms in the human body. It is involved in a
Introduction Spinal cord injury (SCI) can lead to severe impairments in motor, sensory, and autonomic nervous system functions. It has been reported that motor function recovery can be promoted by mediatin
Introduction Chronic cerebral hypoperfusion (CCH) has been identified as one of the initial conditions critical to the development of cognitive impairment, which is tightly associated to the complex neurologic
Introduction Stroke remains the second leading cause of death and the third leading cause of death and disability combined in the world, as reported in 2019 Global Burden of Disease Study. Ischemic stroke
Introduction Myocardial ischemia/reperfusion (MI/R) can damage the heart muscle, which may contribute to further cardiomyocyte death. Following percutaneous coronary intervention therapy, patients with MI/
Introduction According to the report by World Health Organization (WHO) in 2017, depression is the third leading cause of the global disease burden, with over 300 million people suffering from this disease w
Thanks to our unrelenting dedication to creating cutting-edge solutions that push the frontiers of scientific development, BONTAC has long been at the forefront of the biochemical sector. We are excited to present o
Our unshakable dedication to maximizing the potential of traditional Chinese medicine has propelled BONTAC to the forefront of the natural products sector for a considerable amount of time. We are thrilled to presen
Our unwavering quest of innovation at BONTAC has always been sparked by our profound grasp of the natural world and its unrealized potential. We are excited to present our ground-breaking solutions today, which are
With an unwavering zeal for creating innovative solutions with the potential to revolutionize industries and improve lives, we at BONTAC have long been at the forefront of the green biotechnology revolution. We are
With an unwavering zeal for creating innovative solutions with the potential to revolutionize industries and improve lives, BONTAC has long been at the forefront of the green biotechnology revolution. We are ex
For many years, BONTAC has been acknowledged as a leader in the field of green biotechnology, thanks to our unwavering commitment to creating ground-breaking products and services that have the potential to improve
Because of our unwavering search for products that have the power to genuinely change the lives of our partners and consumers, we at BONTAC have long been at the forefront of cutting-edge green biotechnology solutio
Being deeply aware of the vital role our products play in enabling people to live healthier, more fulfilling lives has always motivated us at BONTAC to innovate. We are pleased to announce our ground-breaking NMNH,
Propelled by an unwavering dedication to innovation and a profound comprehension of the crucial function this coenzyme plays in preserving cellular health and lifespan, BONTAC has been at the forefront of the NAD+ a
Na BONTAC, we have always been driven by a relentless pursuit of innovation – a desire to push the boundaries of what is possible in the realm of nutritional supplements and biomedical research. Today, we are thril
V BONTAC jsme dlouhodobě vášniví pro hledání špičkových nutričních řešení, která mohou skutečně změnit lidské zdraví a pohodu. Dnes s radostí upřednostňujeme jednu z nejpozoruhodnějších
V BONTAC jsme vždy stáli v čele špičkového výzkumu nutraceutik, věnovali jsme se odhalování nejpozoruhodnějších a nejtransformačních sloučenin, které příroda nabízí. Dnes s nadšením vás představujeme
For many years, BONTAC has been at the forefront of innovative biopharmaceutical developments, committed to maximizing the life-changing potential of nature's most extraordinary substances. We are excited to pre
V BONTAC jsme dlouhodobě v čele inovací v oblasti biofarmaceutik, odhodlaní využívat sílu špičkových vědeckých objevů ke zlepšení života těch, kterým sloužíme. Dnes jsme
V BONTAC nás žene hluboký závazek posílit jednotlivce nástroji, které potřebují k dosažení optimálního zdraví a pohody. Jako lídři v oblasti biotechnologií jsme se zasvětili
V BONTAC je naším posláním poskytnout jednotlivcům nástroje, které potřebují k dosažení optimálního zdraví a pohody. Jako průkopník v oblasti biotechnologií jsme se věnovali odhalování hlubokého benefu
V BONTAC jsme hluboce odhodláni posouvat hranice lidského zdraví a pohody. Jako přední inovátor v oblasti biotechnologií jsme se zaměřili na využití neuvěřitelného potenciálu Beta-Nikoti
As a leading player in the world of biotechnology, BONTAC is at the forefront of driving innovation and transforming the industry. Our unwavering commitment to scientific excellence and our deep understanding of the
V BONTAC nás žene neúnavná snaha o inovace a hluboký závazek zlepšovat životy těch, kterým sloužíme. Jako lídři v oblasti buněčného zdraví a omlazení jsme nadšeni, že můžeme představit naše
V BONTAC stojíme v čele průmyslu produktů podporujících metabolismus, poháněni naším neochvějným závazkem k inovacím a úsilí o vědeckou excelenci. Naše zaměření na vývoj špičkových řešení h
Introduction With changes in lifestyles and dietary structure, hyperuricemia shows an increasing prevalence year by year, which may become the second largest metabolic disease after diabetes mellitus, a
Introduction Steviol glycosides are secondary metabolites obtained by extracting and isolating stevia from the herbaceous plant Stevia rebaudiana of the Asteraceae family, with a high degree of sweetness
NAD is an abbreviation for nicotinamide adenine dinucleotide, which is a naturally occurring coenzyme (a substance that works with enzymes) found in our bodies. It helps cells produce energy. However, as we age, NAD
Introduction According to the report of International Agency for Research on Cancer (IARC), there are 19.3 million new cases of malignant tumors and 10 million deaths worldwide in 2020. Malignant tumors have overtaken
Introduction Elderly individuals are at a significantly higher risk for peripheral artery disease (PAD), a common vascular disorder. As the global population ages rapidly, the number of PAD cases is projected to rise
Introduction Diabetic kidney disease (DKD) has emerged as one of the primary cause of mortality among the patients with end-stage renal disease such as renal failure, accounting for 30-50% of chronic renal failure cas
Introduction Nicotinamide adenine dinucleotide (NAD+) metabolism is essential for maintaining normal physiological activities, and the decreased NAD+ level is related to various pathologies such as cardiac dis
Introduction Targeting the autophagy-NAD axis has been reported be a viable therapeutic strategy for Niemann-Pick type C1 (NPC1) disease. The study suggests that both pharmacological rescue of autophagy deficiency and
Introduction Apical periodontitis, an inflammatory disease affecting tooth apex tissues, is triggered by oral pathogens infecting the root canal. One of the main reason for endodontic treatment failure is Enterococcus
Introduction Amoebiasis has emerged as the third most common cause of death by parasites worldwide after malaria and schistosomiasis infections. According to the report of World Health Organization, over 40 milli
Introduction Disturbance in hepatic NAD+ metabolism has been manifested as a key factor in the initiation and progression of nonalcoholic fatty liver disease (NAFLD), one of the most co
Introduction According to the 2017 Commission on Traumatic Brain Injury (TBI), TBI remains one of the top three causes of injury-related death and disability up to 2030. There are 50~60
Introduction In clinical settings, doxorubicin (DOX) is an effective broad-spectrum anti-cancer drug in chemotherapy for various tumors, including hematological malignancies and solid tumors such as leu
Introduction Cigarettes containing nicotine (Nic) and sugar-sweetened beverages (SSBs) with high fructose corn syrup (HFCS) have been uncovered to induce hepatic steatosis, which are the risk factors for the developme
Introduction Acute promyelocytic leukemia (APL), the M3 type of acute myeloid leukemia (AML), typically relies on all-trans retinoic acid (ATRA) as its primary treatment. While APL patients treated with
Introduction Recent research unveils that hepatic insulin resistance (IR) and steatosis in obesity have a strong association with endoplasmic reticulum (ER)-mitochondria miscommunication. Notably,
Aging is an undeniable reality of life. It is a known fact that with increasing age, different body functions tend to decline. While we may not completely stop this decline, we can slow it down with pure NMN po
Introduction In the presence of oxygen, tumors produce adenosine triphosphate (ATP) through glycolysis instead of mitochondrial oxidative phosphorylation, a phenomenon known as the “Warburg effect”. Aerobi
Introduction Age-related macular degeneration (AMD) has become one of the leading cause of low vision and even blindness in the elderly, especially in those above 50. In 2020, approximately 1.8 million people aged ove
Introduction Natural products, including single components or extracts of herbal medicines, have the features of good efficacy and low toxicity when used in tumor treatment. They have unique advantages in treating dis
Introduction Reproductive dysfunction is frequent in female suffering from type 1 diabetes (T1D), up to 40% of whom will develop a variety of reproductive dysfunctions throughout their lives. T1D patients often ha
In today's health and anti-aging fields, NMN (nicotinamide mononucleotide) has attracted a lot of attention. As an important cellular coenzyme, NMN plays a key role in maintaining cell health and delaying the aging p
Introduction Ginsenoside Rg3 (Rg3) holds great promise as a potential drug for preventing scar formation, but it is often difficult for it to work alone due to its poor water solubility and low bioavail
Introduction Lead (Pb) contamination in aquatic environments poses a significant threat to the health and well-being of aquatic organisms, including fish species. There is rising popularity of prebiotics and probi
Elevating Wellness: BONTAC's NMN Powder Offerings As we delve into the realm of health and wellness, the spotlight shines brightly on NMN powder, a powerful supplement embraced by many for its potential benefits.
Innovating Solutions: BONTAC's Biotechnology Product Offerings In the ever-evolving landscape of biotechnology products, BONTAC remains a trailblazer in providing cutting-edge solutions that drive innovation
Revolutionizing Biotechnical Research: BONTAC's Trailblazing Discoveries In the dynamic realm of biotechnical research, BONTAC stands at the forefront of innovation, dedicated to driving progress and breakthr
Elevating Health with BONTAC's Cutting-Edge Longevity Supplements In the realm of health and wellness, the demand for high-quality metabolism-boosting supplements continues to rise. Na BONTAC, we recognize the c
Introduction It has been reported that infection with Gram-negative bacteria can disrupt the osteogenic differentiation. Notably, nicotinamide mononucleotide (NMN) protects against osteogenesis from inflammat
Pioneering Discoveries: BONTAC's Innovations in Biotechnical Research In the dynamic realm of biotechnical research, BONTAC stands at the forefront of innovation, dedicated to driving progress and breakthroug
Výživné zdraví: BONTAC jako přední dodavatel surovin doplňků As a prominent raw material supplier of supplements, BONTAC is dedicated to developing and delivering premium products that promote he
Unleash Vitality and Renewal: BONTAC's Cutting-edge Cellular Rejuvenation Solutions Cellular Rejuvenation plays a vital role in enhancing vitality and promoting overall wellness. Na BONTAC, we are dedicated t
Introduction Hepatocellular carcinoma (HCC) is hypervascular solid tumor with rapid deterioration, poor overall prognosis and a high recurrence rate, accounting for 90% of primary liver cancers, which ha
Zlepšení zdraví: BONTAC pokročilé suroviny pro doplňky buněčné zdraví In today's fast-paced world, the quest for optimal health and wellness has led to a surge in the demand for high-quality cellular
Powering Health and Vitality: BONTAC's Metabolism-boosting Product Portfolio In the dynamic landscape of health and wellness, the demand for cutting-edge metabolism-boosting products continues to
Unlocking the Power of Metabolism-Boosting Supplements: A Guide by BONTAC In the realm of health and wellness, the demand for high-quality metabolism-boosting supplements is steadily rising. Na BONTAC,
Introduction Artificial insemination with chilled ram semen is commonly used method in livestock industry. But storing sperm in chilled conditions may cause changes in sperm membrane function and structure, and
Introduction In light of a statistics report by World Health Organization (WHO), there are 18 million people suffering from rheumatoid arthritis (RA) worldwide in 2019, where the prevalence of female is 2.5 times
Introduction Glaucoma is regarded as the second dominant cause of blindness across the world. With the amounting number and proportion of elderly people, it is estimated that 111.8 million people will have glaucom
Introduction Triocresyl phosphate (TOCP) is widely used in the realm of industry and agriculture in the last century. However, it is subsequently banned due to the increasing understanding of its toxicity. In
Introduction Cardiovascular diseases (CVD) poses huge economic burden and great threat to the life of patients, even surpassing Alzheimer's disease and diabetes. 17.9 million people in the world
Introduction Myocardial ischemia-reperfusion (I/R) injury has emerged as an urgent clinical issue that may offset the benefits of reperfusion therapy and even worsen the prognosis of acute myocardial infarction, a
.two-side{ text-align: justify; display: flex; justify-content: space-between; } Introduction The crucial parts of nicotinamide adenine dinucleotide (NAD+) and its metabolites in aging a
Introduction Ginsenoside Rh2 nanoliposome formulation has been proved to effectively target and deliver drugs to the tumor site, with less side effects and higher treatment efficiency, holding great promise in the
Introduction Replenishing nicotinamide mononucleotide (NMN) to raise the availability of nicotinamide adenine dinucleotide (NAD+) has been deemed as effective approach to prevent neurodegeneration in aging and pat
Introduction Rare ginsenoside Rg3, an active extract from Panax ginseng, is reported to possess a wide range of pharmacological properties including anti-angiogenesis and anti-cancer, with high lipophilicity (esti
Introduction Wound healing is a sophisticated Proces responding to tissue damage, which is associated with numbers of interaction of various cell types, cytokines, growth factors, and other molecules. Strikingly,
Introduction Diabetes is one of the dominant causes of death and disability worldwide, greatly affecting the life quality of patients. According to the latest data on diabetes released by the Lancet (GBD Study 202
Introduction Intervertebral disc degeneration (IDD) is a frequently seen orthopedic disease, which is accompanied with excessive apoptosis of nucleus pulposus cells (NPCs) and degeneration of extracellular ma
Introduction Ginsenoside Rg3 is Panaxanediol type tetracyclic triterpenoid saponin monomer extracted from the root of Panax ginseng, which has a wide range of pharmacological effects including anti-tumor, neuroprotect
Introduction The gut is a diverse and dynamic microbiotic system. There are about 100 trillion microorganisms in the gut, which is mainly composed of anaerobic, partially anaerobic, and aerobic bacteria. In the pr
Introduction Mar 4th is determined as the World Obesity Day. World Obesity Federation, UNICEF and WHO have hosted a global youth-led webinar to talk about obesity & youth. The obesity crisis has gradually attr
Introduction Nicotinamide mononucleotide (NMN), one precursor of nicotinamide adenine dinucleotide (NAD+), has been ascertained to be implicated with multiple biological Proceses such as cellular redox regulation and
Introduction Alpers' disease is both a neurodegenerative disorder and a metabolic disorder, which is tightly linked to mitochondrial dysfunction and mutations in the catalytic subunit of polymerase
Introduction NADH (reduced form of NAD+) serves as a carrier of biological hydrogen and an electron donor, which participates in diverse physiological Proceses such as protein synthesis, DNA repair,
Introduction Ginsenoside Rh2, one protopanaxadiol (PPD)-type rare ginsenoside in Panax ginseng, is uncovered to possibly have broad-spectrum pharmacological activity in diversified tumors. It is utili
Introduction Solute carrier family 25 member 51 (SLC25A51) is perceived as a mammalian transporter, which is capable of importing oxidized nicotinamide adenine dinucleotide (NAD+) into mitochondrial matrix. Remark
Introduction Oxidized form of nicotinamide adenine dinucleotide (NAD+) and its precursor nicotinamide mononucleotide (NMN) have been uncovered to restore DNA repair and prevent cancer progression via the deleted i
1. Introduction Disrupted nicotinamide adenine dinucleotide (NAD+) metabolism is increasingly deemed to be one of risk factor for amendable cardiovascular disorders. A substantial evidence has mirrored that res
1. Introduction Rare ginsenosides, a group of dammarane triterpenoids that exist in low natural abundance, fuels a high concern from scholars recently, showing great potential as shining components in drugs and nu
1. Introduction Nicotinamide adenine dinucleotide (NAD) has been unveiled to be essential for embryonic development. Patients with genetic variants in the NAD+ de novo synthesis pathway often have congen
1. Introduction The gut microbiota has long been regarded as one of the key elements contributing to the regulation of host health. Any changes in the composition or quality of the gut microbiota may have physiolo
1. Introduction Nicotinamide adenine dinucleotide (NAD) compartmentalized in adipocytes can modulate adipocyte differentiation and gene expression, in addition to controlling glucose metabolism. White adipose tiss
1. Introduction Nicotinamide mononucleotide (NMN) supplementation has been suggested to hamper the inflammatory responses via restoring NAD+ level and downregulating the expression of C
1. Introduction Age-related NAD+ depletion affects physiological functions and contributes to various aging-related diseases. NAD+ precursors can significantly elevate NAD+ level in murine tissues, effectivel
1. Introduction In mammalian cells, the majority of NAD+ is produced from metabolites entering the NAD+ salvage pathway. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme of the salvage
Nmnh, známý také jako nikotinamidmononukleotidhydrát, je důležitý koenzym nacházející se ve všech živých buňkách. Hraje klíčovou roli v buněčném metabolismu, produkci energie a různých biosyntetických procesech. Vysoká čistota N
V oblasti doplňků stravy vyniká NADH jako klíčový koenzym zapojený do buněčného metabolismu. Jeho význam pro udržení energetické úrovně a podporu celkové pohody z něj učinil ceněnou ingredienci pro
1. Introduction Nicotinamide Mononucleotide (NMN) has been deemed as a functional nutrient for improving human intestinal health. In this study, an in vitro simulated digestion model
1. Introduction Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that affects the motion-related nerve cells in the brain and spinal cord. The disease is featured by the d
1.Introduction A series of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and Huntington's disease, are accompanied with bioenergetic maladaptations and axonopathy wi
1. Introduction Diabetic peripheral neuropathy (DPN) is one of the most frequent complications of diabetes, ans also a major cause of foot ulcers, disability, and eventual amputation. With the prolongation of the
1.Introduction Mitochondria, a type of highly plastic organelle, can maintain a relatively stable dynamic equilibrium state towards the morphology, structure, quantity, volume, quality, and function
1. Introduction Naherosclerosis is a chronic progressive inflammatory disease, which is featured by the accumulation of lipids in the intima of the arteries with yellow appearance. This disease
1. Introduction Mitochondria are the center of energy metabolism in cardiomyocytes, which are necessary for maintaining normal myocardial contractility and cardiac function. Typically, the de
1. Introduction According to the 2020 report of World Health Organization (WHO), there are approximately 2.3 million cases with breast cancer worldwide. Breast cancer has emerged as one of the
1.Introduction The senescence in mammals is generally concomitant with the dysregulation of intestinal homeostasis and the accumulation of mitochondrial DNA (mtDNA) mutations. High-burden mtDNA mutations lead to N
1. Introduction Na present, vaccine is the preferred option for the prevention of foot-and-mouth disease (FMD), for which the adjuvant is essential due to its strong role in boosting immune response associated wi
1. Introduction Acute lung injury comprises a uniform response of the lung to inflammatory or chemical insults which is commonly caused by systemic illness including sepsis or trauma, infection with pathogens, and tox
1. Introduction Gastric cancer (GC) represents a global health-care challenge, which is the fifth most common cancer and the fourth leading cause of cancer death across the world in 2020, with a significant
1. Introduction Supplementation of nicotinamide mononucleotide (NMN) to upregulate the level of nicotinamide adenine dinucleotide (NAD+) has been unveiled to be a promising anti-aging intervention. However, it is
1.Introduction Nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), also known as reduced coenzyme II, is a critical cofactor in cellular antioxidant systems and lipid synthesis, which links insulin
1. Introduction Dengue fever is an acute infectious disease caused by the Dengue virus through the bite of an infected Aedes species (Ae. aegypti or Ae. albopictus) mosquito, with the main symptoms such as hi
1. Introduction The NAD precursor nicotinamide mononucleotide (NMN) shows a beneficial effect on ageing, yet excessive NMN accumulation may lead to axon degeneration. How to make the anti-ageing
1 Introduction Nicotinamide riboside (NR), a derivative of vitamin B3, is a new type of bioactive substance, which can be generated by binding a carbohydrate molecular ribose with nicotinamide (a
1. Introduction Heart failure is a serious condition in the development of cardiovascular disease. In particular, diastolic heart failure, as one of the most common manifestations of heart failure in
1. Introduction Ginseng has always been highly perceived as a valuable traditional Chinese medicine in China. Currently, much attention also has been paid to ginsenosides, the main active ingredients extracted from g
1. Introduction On July 2023, the World Health Organization (WHO) has classified the soda sweetener aspartame as a possible carcinogen, but said that aspartame is safe to consume with
Myocardial mitochondria are primary sites of myocardial energy metabolism. Mitochondrial disorders are associated with various cardiac diseases. Mitochondrial translation defects cause not only mitochondrial
Zánětlivá reakce a narušení kožní bariéry způsobené oxidačním stresem hrají klíčovou roli v procesu atopické dermatitidy (AD). Hladiny lipidové peroxidace jsou často vyšší u pacientů s AD, zatímco antio
Vitamín D a B3 (niacin) by mohly pomoci aktivaci imunitního systému a rekonstituci CD4+ T buněk v INR. NAD, který je zásadní pro buněčnou funkci, s věkem ubývá a souvisí s různými nemocemi. Podporovatelé NAD jako NMN, NR a NAM ukazují ples
Sepsis, marked by dysregulated infection response, lacks effective treatment. NAD+'s role in inflammation remains unclear. NAD+ transport challenges limit its therapeutic impact. Novel NAD+-loaded nanoparticles (NPs)
V klinické diagnostice jsou enzymy důležitými biokatalyzátory a hrají klíčovou roli v mnoha biochemických reakcích. Tyto enzymy vyžadují koenzymy, které nazýváme diagnostickými koenzymy s reagenciemi, aby mohly vykonávat své funkce.
Hematoencefalická bariéra (BBB) je klíčovou součástí centrálního nervového systému, která reguluje výměnu molekul mezi mozkem a krevním oběhem. Věkové změny v BBB mohou vést ke zvýšení na
Cévní demence je jedním z vážných a nevratných syndromů nabytého poškození inteligence způsobeného sérií cerebrovaskulárních onemocnění. Citikolin je derivací nukleo-strany, která nemůže pouze exhi
In the quest for a healthier lifestyle, the sweetener debate continues to rage. While sugar has long been the default choice, its adverse health effects have prompted a search for alternatives. One such swe
The nicotinamide adenine dinucleotide (NAD+ )/reduced NAD+ (NADH) and NADP+/reduced NADP+ (NADPH) redox couples are essential for maintaining cellular redox homeostasis and for modulating numerous biologic
Hypertenze je významným globálním zdravotním problémem, spojeným s miliony úmrtí v důsledku kardiovaskulárních problémů. Zahrnuje dysfunkci endotelu a ztuhlost tepen, což přispívá k aterosklerotickým onemocněním. Zlepšování VA
Diety s vysokým obsahem cukru vedly k rostoucímu výskytu různých chronických onemocnění, včetně obezity, cukrovky, kardiovaskulárních onemocnění a hypertenze, což představuje významný globální problém pro veřejné zdraví. Stevia Rebaudiosid
CFS is a disorder of unknown etiology, consisting of prolonged, debilitating fatigue, and a multitude of symptoms including neurocognitive dysfunction, flu-like symptoms, myalgia, weakness, arthralgia, low-grade fev
Alkohol je druh psychoaktivní látky, která se běžně používá v několika kulturách po staletí. Příjem alkoholu je hlavní příčinou akutního poškození jater a chronického onemocnění jater. Alkoholismus může člověka urychlit
Stevia (Stevia rebaudiana Bertoni), vytrvalý keř z čeledi Compositae, se pěstuje v mnoha regionech po celém světě. Je známý svou sladkostí, která je způsobena přítomností steviolových glykosidů, které obsahují 1
Steviosid je přírodní sladidlo získané z rostliny stévie. Má vysokou sladkost a nízký kalorický obsah, což ho činí atraktivním pro diabetiky i další osoby na dietách s omezenými sacharidy. Nicméně stevios
Highlight: In chronic HBV infection elevated ROS production is associated to high DNA damage in HBV-specific CD8 T cells - Response to DNA damage is dysfunctional - Up-regulation of CD38 and persistent activatio
In the pass decades days, the Open AI and the amazing founder behind AI application both captured attention world widely. But recently, as MIT Technology Review reported, the OpenAI CEO Sam Altman has turned ou
NMNH výrazně zvyšuje hladinu NAD+ a potlačuje glykolýzu, TCA cyklus a růst buněk NAD+ is essential for biological Proceses such as metabolism and DNA repair, and its decline is associated with age-related diseas
Ginsenosides on Cancer and Related Clinical Studies Cancer is a leading cause of death globally, and its treatment often involves a combination of surgery, chemotherapy, and radiation therapy. These treatm
Růstově spřahané enzymové inženýrství manipulací s regenerací redoxních kofaktorů An increasingly wide range of chemicals are now being produced from renewable feedstocks through biotechnological means. Biopro
Supervision Policies for NMN in Japan, China, America, Australia and Canada The mainstream researches of NMN have been conducted since a decade years ago. The United States had already carried out its commerciali
Collections of Clinical Trails on NMN Oral Administation NMN, as one of NAD+ booster family critical members, become increasingly popular on the market in the filed of health pomoting. And to date, there are
S uvolněním politik kontroly epidemie po celém světě trpí obyvatelé Číny, Indie, Malajsie, Japonska a Singapuru nedostatkem léků v různé míře. Na druhou stranu, typ léků
Natention! The Cambridge University Researchers Found Ursodeoxycholic Acid (UDCA) Can Prevent and Treat Covid-19 The International academic journal Nature published an article titled FXR inhibition may protect from SARS
Dne 10. srpna 2021 publikovali výzkumníci ze Šanghajské univerzity vědy a techniky článek s názvem NAD+ doplněk zesiluje funkci zabíjející nádory tím, že zachraňuje vadný TUBBY-mediatovaný NAMPT transkrip
