Advantages of NMNH
NMNH: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder. 2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability. 3. Exclusive “Bonpure” seven-step purification technology, high purity（up to 99%) and stability of production of NMNH powder 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder 5. Provide one-stop product solution customization service
Advantages of NADH
NADH: 1. Bonzyme whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive Bonpure seven-step purification technology, purity up higher than 98 % 3. Special patented process crystal form, higher stability 4. Obtained a number of international certifications to ensure high quality 5. 8 domestic and foreign NADH patents, leading the industry 6. Provide one-stop product solution customization service
Advantages of NAD
NAD: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Stable supplier of 1000+ enterprises around the world 3. Unique “Bonpure” seven-step purification technology, higher product content and higher conversion rate 4. Freeze drying technology to ensure stable product quality 5. Unique crystal technology, higher product solubility 6. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products
Advantages of MNM
NMN: 1. “Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive“Bonpure”seven-step purification technology, high purity（up to 99.9%) and stability 3. Industrial leading technology: 15 domestic and international NMN patents 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products 5. Multiple in vivo studies show that Bontac NMN is safe and effective 6. Provide one-stop product solution customization service 7. NMN raw material supplier of famous David Sinclair team of Harvard University
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Bontac Bio-Engineering (Shenzhen) Co., Ltd. (hereafter referred to as BONTAC) is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. There are six major series of products in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates.
As the leader of the global NMN industry, BONTAC has the first whole-enzyme catalysis technology in China. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields. BONTAC adheres to independent innovation, with more than 170 invention patents. Different from the traditional chemical synthesis and fermentation industry, BONTAC has advantages of green low-carbon and high-value-added biosynthesis technology. What’s more, BONTAC has established the first coenzyme engineering technology research center at the provincial level in China which also is the sole in Guangdong Province.
In the future, BONTAC will focus on its advantages of green, low-carbon and high-value-added biosynthesis technology, and build ecological relationship with academia as well as upstream/downstream partners, continuously leading the synthetic biological industry and creating a better life for human beings.
NMNH is more potent than NMN
When applied to cultured cells, the NMNH is shown to be more efficient than NMN as it was able to “significantly increase NAD+ at a ten times lower concentration (5 µM) than that needed for NMN”. Moreover, NMNH shows to be more effective , as at 500 µM concentration, it achieved “an almost 10-fold increase in the NAD+ concentration, while NMN was only able to double NAD+ content in these cells, even at 1 mM concentration.”.
Interestingly, NMNH also appears to act quicker and has a longer-lasting effect compared to NMN. According to the authors, NMNH induces a “significant increase in NAD+ levels within 15 minutes”, and “NAD+ steadily increased for up to 6 hours and remained stable for 24 hours, while NMN reached its plateau after only 1 hour, most likely because the NMN recycling pathways to NAD+ had already become saturated.”.
NADH powder manufacturing method
The main methods of NMNH powder preparation include extraction, fermentation, fortification, biosynthesis and organic matter synthesis. Compared with other preparations, the whole enzyme becomes the mainstream method owing to the advantages of pollution free, high level of purity and
BONTAC NMNH product features and advantages
1. "Bonzyme" Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder.
2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability.
3. Exclusive “Bonpure” seven-step purification technology, high purity (up to 99%) and stability of production of NMNH powder
4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder
5. Provide one-stop product solution customization service
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Frequently Asked Question
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NADH is synthesized by the body and thus is not an essential nutrient. It does require the essential nutrient nicotinamide for its synthesis, and its role in energy production is certainly an essential one. In addition to its role in the mitochondrial electron transport chain, NADH is produced in the cytosol. The mitochondrial membrane is impermeable to NADH, and this permeability barrier effectively separates the cytoplasmic from the mitochondrial NADH pools. However, cytoplasmic NADH can be used for biologic energy production. This occurs when the malate-aspartate shuttle introduces reducing equivalents from NADH in the cytosol to the electron transport chain of the mitochondria. This shuttle mainly occurs in the liver and heart.
Nicotinamide adenine dinucleotide (NAD+ ) homeostasis is constantly compromised due to degradation by NAD+ -dependent enzymes. NAD+ replenishment by supplementation with the NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) can alleviate this imbalance. However, NMN and NR are limited by their mild effect on the cellular NAD+ pool and the need of high doses. Here, we report a synthesis method of a reduced form of NMN (NMNH), and identify this molecule as a new NAD+ precursor for the first time. We show that NMNH increases NAD+ levels to a much higher extent and faster than NMN or NR, and that it is metabolized through a different, NRK and NAMPT-independent, pathway. We also demonstrate that NMNH reduces damage and accelerates repair in renal tubular epithelial cells upon hypoxia/reoxygenation injury. Finally, we find that NMNH administration in mice causes a rapid and sustained NAD+ surge in whole blood, which is accompanied by increased NAD+ levels in liver, kidney, muscle, brain, brown adipose tissue, and heart, but not in white adipose tissue. Together, our data highlight NMNH as a new NAD+ precursor with therapeutic potential for acute kidney injury, confirm the existence of a novel pathway for the recycling of reduced NAD+ precursors and establish NMNH as a member of the new family of reduced NAD+ precursors.
First, inspect the factory. After some screening, NMNH companies that directly face consumers pay more attention to brand building. Therefore, for a good brand, quality is the most important thing, and the first thing to control the quality of raw materials is to inspect the factory. Bontac company actually manufacturing NMNH powder of high quality with the caterias of SGS. Secondly, the purity is tested. Purity is one of the most important parameters of NMN powder. If high purity NMNH cannot be guaranteed, the remaining substances are likely to exceed the relevant standards. As the attached certificates demonstrates that the NMNH powder produced by Bontac reach the purity of 99%. Finally, a professional test spectrum is needed to prove it. Common methods for determining the structure of an organic compound include Nuclear Magnetic Resonance Spectroscopy (NMR) and high-resolution mass spectrometry (HRMS). Usually through the analysis of these two spectra, the structure of the compound can be preliminarily determined.
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The Significance of NAD+ in Intestinal Senescence Caused by Elevated mtDNA Mutations
1.Introduction The senescence in mammals is generally concomitant with the dysregulation of intestinal homeostasis and the accumulation of mitochondrial DNA (mtDNA) mutations. High-burden mtDNA mutations lead to NAD+ depletion and activate the transcription factor ATF5-dependent UPRmt, which in turn promotes and exacerbates the intestinal senescence phenotype. By supplementation with the NAD+ precursor NMN, this intestinal senescence phenotype can be rescued to some extent, as evidenced by the recovery of intestinal organoid differentiation and the increased number of intestinal stem cells. 2. NAD+ depletion during intestinal senescence caused by mtDNA mutations There is impairment of NADH/NAD+ redox in Mut/Mut*** intestines, as manifested by the enriched NADH dehydrogenase complex assembly pathway. Through transfection of intestinal crypt cells with SoNar (a NADH/NAD+ sensor), a higher NADH/NAD+ ratio is observed in Mut/Mut*** mice, hinting the perturbed redox potential. Likewise, following transfection of intestinal crypt cells with FiNad (a NAD+ sensor), less NAD+ content is discovered in the Mut/Mut*** cells. All of these findings mirror NAD+ depletion in the intestinal senescence triggered by mtDNA mutations. Note: mtDNA mutations are classified into four types: negligible (WT/WT), low (WT/WT*), moderate (WT/Mut**) and high (Mut/Mut***). 3. The link between mtDNA mutation content and physiological intestinal senescence The small intestine of aged mouse intestine is characterized by decreased intestinal crypt number, increased villus length, higher expression of CDKN1A/p21 (a well-known senescence marker) and shorter telomere length, which is accompanied by accumulation of mtDNA mutations, primarily low-frequency (less than 0.05) point mutations. 4. LONP1 protein as a candidate marker for intestinal senescence caused by accumulated mtDNA mutations Mitochondrial unfolded protein response (UPRmt) is activated by a variety of mitochondrial stresses, including protein imbalances between mitochondria and the nucleus as well as impaired mitochondrial protein transport. The hallmarks of UPRmt are increased protein expression levels of LONP1, HSP60 and ClpP. Noteworthily, only LONP1 protein is specifically upregulated in senescent UPRmt activation triggered by accumulated mtDNA mutations, which may be a candidate biomarker for intestinal senescence. 5. The role of NAD+ in intestinal senescence induced by elevated mtDNA mutations. NAD+ repletion in vivo alleviates the small intestine senescent phenotypes caused by mtDNA mutation burden, and rescues the decreased colony formation efficiency in Mut/Mut*** intestinal organoids. NAD+-dependent UPRmt triggered by mtDNA mutations regulates intestinal senescence. These data further indicate that NAD+ depletion functions as a key mediator of the intestinal senescence induced by accumulated mtDNA mutations. 6. The role of NAD+ in the signal pathways regulating intestinal senescence caused by increased mtDNA mutations NAD+ repletion rescues the Foxl1 downregulation and Notch1 upregulation in Mut/Mut*** mice, suggesting that mtDNA mutation burden can regulate the function or number of niche cells through NAD+ depletion. In addition, NAD+ depletion caused by increased mtDNA mutation burden induces the decline of LGR5-positive intestinal cells via impairment of the Wnt/β-catenin pathway. 7. Conclusion NAD+ repletion is significant for the regulation of intestinal homeostasis, playing a critical role in rescuing the intestinal senescence phenotype caused by accumulated mtDNA mutations. Reference Yang, Liang et al. “NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations.” Nature communications vol. 15,1 546. 16 Jan. 2024, doi:10.1038/s41467-024-44808-z About BONTAC BONTAC is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. BONTAC has over 160 domestic and foreign patents, leading the industry of coenzyme and natural products. BONTAC has rich R&D experience and advanced technology in the biosynthesis of NAD and NMN. High quality and stable supply of products can be ensured here. Disclaimer This article is based on the reference in the academic journal. The relevant information is provide for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC.
BONTAC: A model of High Quality NMN Manufacturer Factory
In today's health and anti-aging fields, NMN (nicotinamide mononucleotide) has attracted a lot of attention. As an important cellular coenzyme, NMN plays a key role in maintaining cell health and delaying the aging process. However, it is not easy to find a manufacturer that can provide high-quality NMN. Here, we will introduce BONTAC, a High Quality NMN Manufacturer Factory. BONTAC: Focus on the production of NMN BONTAC is a company specializing in the development and production of biochemical products, including NMN. They have advanced production equipment and technology, as well as a team of experienced scientists and engineers, dedicated to providing high-quality NMN. Their R&D team continues to explore and innovate to ensure that their NMN products are always at the forefront of the industry. High quality NMN BONTAC's NMN products are known for their high purity and stability. Their NMN is produced in a strictly controlled environment to ensure its quality and purity. In addition, they undergo rigorous quality testing on each batch of products to ensure it meets the highest quality standards. Their quality control team strictly monitors every step of production, from the selection of raw materials to the packaging of the final product, to ensure the excellent quality of the products. Customer first BONTAC not only provides high-quality products, but also provides excellent customer service. Their team is always customer-oriented and provides customized solutions to meet the needs of different customers. Whether you are a large enterprise or a small research institution, BONTAC can provide the services you need. Their customer service team is always ready to provide customers with professional consultation and support to ensure that their needs are met. Conclusion BONTAC is a High Quality NMN Manufacturer Factory, the high quality NMN and excellent customer service they provide make them stand out in the industry. If you are looking for a reliable NMN supplier, BONTAC is undoubtedly an option worth considering. Their expertise, strict quality control and excellent customer service have earned them an excellent reputation in the NMN manufacturing field. Whether you are a consumer or a researcher, when you choose BONTAC, you will receive the highest quality NMN products and services. Let us look forward to BONTAC bringing more innovations and breakthroughs in the future, opening up more possibilities for our health and longevity.
What is Pure NMN Powder? Its Potential Benefits and 4 Basic Applications
Aging is an undeniable reality of life. It is a known fact that with increasing age, different body functions tend to decline. While we may not completely stop this decline, we can slow it down with pure NMN powder. NMN powder—Nicotinamide Mononucleotide—is a derivative of Vitamin B3 (Niacin). It is a potent anti-aging molecule that helps counter the effects of growing age. Moreover, it increases overall body energy, reducing tiredness. In simpler words, NMN is a total game changer in age vs. health combat! So, what is NMN powder, and how can you use it to maximize your health? Read on to find out all. What is Beta-Nicotinamide Mononucleotide (NMN)? NMN, or Beta-Nicotinamide Mononucleotide, is a precursor molecule of NAD+ (Nicotinamide Adenine Dinucleotide) in the body. Research has shown that NAD+ combines with particular molecules called sirtuins to enhance longevity, which is achieved by converting food molecules into energy packets that are later used to carry out bodily functions[1]. NAD+ is also a crucial component of the body's age cycle. It regulates cellular health by acting on anti-aging genes and turning them on and off to regulate metabolism. However, NAD+ only has limited body stores. Therefore, a decrease in NAD+ leads to aging. Pure NMN powder prevents this decline by complementing the NAD+ deficiency, ultimately leading to a better life expectancy. Potential Benefits of Pure NMN Powder David Sinclair, a Harvard professor of genetics, has been working on the benefits of pure NMN powder for aging for decades. According to David Sinclair's NMN research and existing studies, the role of NMN is that of an activator. Based on this role, NMN provides the following benefits to the body: 1. May Boost NAD+ Levels in the Body Acting as a moderator, NMN converts NAD into activated forms. It helps increase energy production in the body, making you feel energized. The activated NAD+ then performs vital functions of the body, like: * Reduced inflammation * Stress resistance * Maintaining circadian rhythms * DNA repairs * Boosting energy metabolism * Improving athletic performance 2. May Improve Metabolic Health and General Wellness Pure NMN powder raises NAD+ levels throughout your body. With a healthy diet and lifestyle, it may be helpful for old-age problems and chronic diseases, improving overall health. These might include: * Protect the cardiovascular and cerebrovascular * Prevent cancer * Regulates blood sugar * Help with weight loss * Improve sleeping * Prevent neurodegenerative diseases * Auxiliary hypolipidemic * Auxiliary hypoglycemic * Hearing and vision protectionPromote alcohol metabolism, hangover and protect the liver 3. May Offer Anti-Aging Effects NAD+ is a key player in our body's energy production and DNA repair processes. Pure NMN powder holds promise as a potential anti-aging agent by bolstering intracellular NAD+ levels. NMN may exert further anti-aging effects by enhancing mitochondrial function and potentially lengthening telomeres. Though the precise mechanisms underlying NMN's anti-aging properties are still under investigation, its potential to support cellular health and longevity by utilizing pure NMN powders effectively. Top 4 Applications of Pure NMN Powder Pure NMN can stand as a versatile supplement and is easily incorporated into our daily lives. Common dosage forms of NMN products may include capsules, tablets, granules, powder, candies, and beverages. With its potential benefits, pure NMN powder finds utility across multiple fields: 1. Health Care Products NMN supplements are used to treat a variety of health conditions. It is touted for its anti-aging properties and potential benefits for metabolism and overall health. Whether it's being used in an anti-aging supplement or a sleep aid, pure NMN powder holds promise for potentially slowing the effects of aging or enhancing sleep quality. 2. Cosmetic Raw Materials NMN also improves skin metabolism by boosting NAD+ production. It further helps to fight off skin problems, increases new regeneration, and creates a glow from within. It is widely used in some anti-aging skincare formulations and for moisturizing and repairing cosmetic products. 3. Functional Food Additives Pure NMN powder is also a functional food additive. It enhances mental concentration and physical vigor, particularly in situations demanding sustained energy. It is frequently found in energy drinks and various health foods like energy bars, gummies, and cereals. 4. Animal Health Last but not least, animal health also benefits from NMN powder. When used in medical treatments and animal feeds, they help boost overall physiological functions and promote vitality. It helps increase the overall life span of animals. BONTAC's Premium Quality Wholesale Pure NMN Powder The efficacy of NMN depends on the quality and purity of the product. Thus, always use high-quality and original NMN products for ideal results. BONTAC is a well-known brand among bio-engineered NMN suppliers. We are the raw material supplier for the NMN study of David Sinclair's team. At the same time, we are also the sole provider of raw materials for clinical trials in many well-known institutions in Japan and the United States. We are known for our premium-quality, pure NMN powder. Our NMN powder is white with no visible impurities. It has a unique smell and a balanced pH (3.0-4.0), offering up to 99.5% purity. Our product advantages include: * 21 domestic and international NMN patents and multiple international certifications * Exclusive “Bonpure” seven-step purification technology, high purity (up to 99.9%) and stability * “Bonzyme” whole-enzymatic method, no harmful solvent residues, environmental-friendly * Multiple in vivo studies show that BONTAC NMN is safe and effective * One-stop customized product solution * Self-owned factories, high quality and stable supply of products All these leading industrial technologies and advantages make BONTAC the best NMN supplier in the biotech industry. IFrame Source: https://www.youtube.com/watch?v=FYkkJfuwttg Final Thoughts NMN has great potential for skin, heart, gut, and aging concerns. When you choose BONTAC, expect nothing but pure NMN powder of unparalleled purity and quality. BONTAC also offers wholesale purchases of NMN powder bulk and a one-stop solution for large businesses. Contact us and get the latest information on product availability. References [1] Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821238/ (Accessed: 6 May 2024)